Urea transport

Across TCGA cell cohorts, RNA activity of the Urea transport pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AQP7, AQP10, and POU3F3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AQP7 grouped by Urea transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AQP7 →	-0.302	-1.314	<.001	<.001	3	8
SKIN	AQP10 →	-0.228	-1.240	.009	.003	2	8
CNS	POU3F3 →	-0.167	-0.823	<.001	.001	3	7
STOMACH	AQP8 →	-0.188	-1.399	.006	.001	3	5
OVARY	H1-0 →	-0.369	-1.489	<.001	<.001	3	4
KIDNEY	ATP1B4 →	-0.250	-0.904	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AQP7 by Urea transport activity — OVARY

Explore this box plot interactively →