Amine transport

Across TCGA patient cohorts, RNA activity of the Amine transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR44, POLD1, and RCC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amine transport activity versus WDR44 in BRCA (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WDR44 →	+0.240	+0.024	<.001	.002	3	6
LSCC	POLD1 →	-0.307	-0.028	.007	.006	3	6
BRCA	RCC2 →	-0.284	-0.027	.004	<.001	3	6
GBM	UTP14A →	-0.267	-0.062	<.001	<.001	3	6
GBM	PRPF19 →	-0.194	-0.036	<.001	.008	3	6
PDAC	SNRPD3 →	-0.340	-0.030	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015837 vs WDR44 — BRCA

Explore this scatter interactively →