Amine transport

Across TCGA cell cohorts, RNA activity of the Amine transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXD4L4, TOR4A, and PEX26, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amine transport activity versus FOXD4L4 in PANCREAS (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FOXD4L4 →	-0.186	-0.414	<.001	<.001	3	2
PANCREAS	TOR4A →	-0.930	-0.414	<.001	<.001	3	2
PANCREAS	PEX26 →	-0.806	-0.448	<.001	.006	3	2
PANCREAS	PLEKHG6 →	-0.519	-0.407	.005	.004	3	2
OESOPHAGUS	H2AC13 →	+1.244	+2.091	.004	.002	3	1
UPPER_AERODIGESTIVE_TRACT	ITPRIPL2 →	+0.960	+0.294	.001	.008	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015837 vs FOXD4L4 — PANCREAS

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