L-serine transport

Across TCGA patient cohorts, RNA activity of the L-serine transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC1A4, TRRAP, and SLC1A5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-serine transport activity versus SLC1A4 in LSCC (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC1A4 →	+0.609	+0.056	<.001	<.001	3	5
GBM	TRRAP →	-0.220	-0.105	<.001	<.001	3	5
UCEC	SLC1A5 →	+1.367	+0.114	<.001	<.001	3	4
OV	KIAA0319L_T974 →	-0.663	-0.085	.007	.002	3	4
OV	AARS1 →	+0.320	+0.050	.001	.007	3	4
GBM	TKT →	+0.328	+0.090	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015825 vs SLC1A4 — LSCC

Explore this scatter interactively →