L-leucine transport

Across TCGA cell cohorts, RNA activity of the L-leucine transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOBTB3, MED15, and ECHDC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RHOBTB3 grouped by L-leucine transport-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RHOBTB3 →	-0.270	-0.230	.001	.001	3	5
SKIN	MED15 →	+0.154	+0.068	.008	.003	3	4
LUNG_NSCLC_LUSC	ECHDC3 →	+0.101	+0.199	.008	.001	3	4
BLOOD_Myeloma	TMED7 →	-0.215	-0.167	.004	.001	3	4
BLOOD_Myeloma	DGKB →	-0.242	-0.147	<.001	.001	3	4
CNS	ZNF526 →	+0.201	+0.117	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RHOBTB3 by L-leucine transport activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →