Isoleucine transport

Across TCGA patient cohorts, RNA activity of the Isoleucine transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUCKS1_S19, RPS8_T130, and MNDA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoleucine transport activity versus NUCKS1_S19 in PDAC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NUCKS1_S19 →	-0.458	-0.053	<.001	.004	3	6
LUAD	RPS8_T130 →	+0.445	+0.059	.007	.001	3	6
GBM	MNDA →	+0.861	+0.088	<.001	<.001	3	6
HNSC	PPP2R1B →	+0.498	+0.090	<.001	<.001	3	5
BRCA	PSMA5_S16 →	+0.723	+0.058	<.001	.001	3	5
GBM	S100A12 →	+1.066	+0.078	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015818 vs NUCKS1_S19 — PDAC

Explore this scatter interactively →