Isoleucine transport

Across TCGA pan-cancer cohorts, RNA activity of the Isoleucine transport pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRC and BLCA, show the opposite pattern, with lower activity in tumor tissue.

COAD, KIRC, and BLCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Female	II,III,IV	+0.073	<.001	9	view →
KIRC	All	All	−0.062	<.001	8	view →
BLCA	Male	IV	−0.087	.004	7	view →
UCEC	All	All	+0.088	<.001	6	view →
KIRP	All	All	−0.075	.001	6	view →
LIHC	All	All	+0.042	<.001	5	view →
THCA	All	All	−0.045	<.001	4	view →
CHOL	All	All	+0.077	.017	2	view →
BRCA	Female	II,III,IV	−0.024	.010	2	view →
LUAD	All	II,III,IV	+0.029	.028	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:0015818–COAD

Open the COAD breakdown →