Isoleucine transport

Across TCGA patient cohorts, RNA activity of the Isoleucine transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM150B, TLR7, and TRAV17, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isoleucine transport activity versus TMEM150B in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TMEM150B →	+0.582	+0.129	<.001	.005	3	5
GBM	TLR7 →	+0.736	+0.179	.001	<.001	3	5
BRCA	TRAV17 →	+0.671	+0.395	.001	.002	3	5
BRCA	CD38 →	+0.882	+0.492	.007	.004	3	4
HNSC	LY9 →	+0.405	+0.152	.005	<.001	3	4
HNSC	PTPN22 →	+0.833	+0.200	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015818 vs TMEM150B — GBM

Explore this scatter interactively →