Isoleucine transport

Across TCGA cell cohorts, RNA activity of the Isoleucine transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCAF1, YWHAH, and RGS19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SCAF1 grouped by Isoleucine transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SCAF1 →	+0.450	+1.014	.002	<.001	3	4
CNS	YWHAH →	+0.684	+0.810	.003	.004	3	4
UPPER_AERODIGESTIVE_TRACT	RGS19 →	+1.108	+1.714	.008	<.001	3	4
CNS	ARID5A →	+1.044	+1.392	.001	<.001	3	4
LUNG_NSCLC_LUAD	NOP53 →	-0.505	-0.925	.006	.002	3	4
PANCREAS	OR7C1 →	+0.039	+1.309	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SCAF1 by Isoleucine transport activity — CNS

Explore this box plot interactively →