L-glutamate transmembrane transport

Across TCGA patient cohorts, RNA activity of the L-glutamate transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLIN2, CPE, and ARFIP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-glutamate transmembrane transport activity versus PLIN2 in BRCA (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLIN2 →	-0.884	-0.733	.003	.002	3	4
UCEC	CPE →	-0.997	-0.501	.001	<.001	3	3
BRCA	ARFIP2 →	+0.623	+0.588	<.001	.005	3	3
OV	BMPR1B →	+0.975	+0.127	.003	.003	3	3
GBM	PRRT3 →	+0.538	+0.395	<.001	<.001	3	3
GBM	ADAP1 →	+0.502	+0.280	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015813 vs PLIN2 — BRCA

Explore this scatter interactively →