Gamma-aminobutyric acid transport

Across TCGA patient cohorts, RNA activity of the Gamma-aminobutyric acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GDI1, ABAT, and ACAP1_T739, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-aminobutyric acid transport activity versus GDI1 in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GDI1 →	+0.286	+0.089	.005	<.001	3	5
BRCA	ABAT →	+0.839	+0.033	<.001	.006	3	5
GBM	ACAP1_T739 →	-0.650	-0.095	.008	.001	3	5
LSCC	TACC2 →	+0.480	+0.065	<.001	<.001	3	5
LSCC	ALDH5A1 →	+0.551	+0.061	<.001	<.001	3	5
OV	GCSH →	+0.559	+0.031	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015812 vs GDI1 — GBM

Explore this scatter interactively →