Gamma-aminobutyric acid transport

Across TCGA pan-cancer cohorts, RNA activity of the Gamma-aminobutyric acid transport pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 19 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Gamma-aminobutyric acid transport pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and LAML, show the opposite pattern, with higher activity associated with better survival.

KIRP, STAD, and LAML are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.709	0.338	<.001	114	view →
STAD	DFS	Median	IV	0.143	0.447	.008	57	view →
LAML	DFS	Quartile	All	0.619	0.327	<.001	36	view →
THCA	DFS	Quartile	II,III,IV	0.935	0.513	.007	35	view →
SARC	OS	Median	All	0.825	0.677	.002	27	view →
BRCA	DFS	Median	II,III,IV	0.923	0.859	.001	24	view →
MESO	DFS	Tertile	III,IV	0.118	0.622	.006	24	view →
ACC	OS	Median	All	0.748	0.517	.016	23	view →
UVM	OS	Median	All	0.925	0.761	.008	21	view →
COAD	DFS	Tertile	All	0.718	0.850	.009	13	view →
UCEC	OS	Median	IV	0.742	0.322	.010	12	view →
LUAD	DFS	Median	IV	0.388	0.755	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0015812–KIRP (DFS)

Open the KIRP breakdown →