Gamma-aminobutyric acid transport

pathway activity — cross-omics
GO:0015812Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Gamma-aminobutyric acid transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABAT, LIFR-AS1, and STAB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVABAT →+1.151+0.915.002<.00135
HNSCLIFR-AS1 →+0.340+0.377.004.00525
GBMSTAB1 →-0.796-0.621<.001<.00134
UCECAPBA1 →+0.517+0.760.001<.00134
GBMC17orf75 →+0.458+0.756<.001<.00134
GBMPLAUR →-0.783-0.669<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration