Gamma-aminobutyric acid transport

Across TCGA cell cohorts, RNA activity of the Gamma-aminobutyric acid transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIO, PXK, and SLC7A14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIO grouped by Gamma-aminobutyric acid transport-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TRIO →	+0.256	+1.253	<.001	.001	3	6
SOFT_TISSUE	PXK →	+0.207	+1.478	<.001	<.001	3	5
BLOOD_Lymphoma	SLC7A14 →	-0.690	-1.642	.009	.009	1	7
BONE	BDKRB2 →	-0.275	-1.924	.009	.007	3	5
KIDNEY	NF1 →	-0.321	-1.365	<.001	.008	2	6
LUNG_NSCLC_LUAD	PGAP3 →	-0.128	-0.711	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIO by Gamma-aminobutyric acid transport activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →