L-cystine transport

Across TCGA cell cohorts, RNA activity of the L-cystine transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MVD, NAA40, and ZNF764, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MVD grouped by L-cystine transport-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MVD →	-1.178	-0.762	.001	.009	3	5
STOMACH	NAA40 →	-0.555	-1.343	.006	<.001	3	5
STOMACH	ZNF764 →	-0.871	-1.602	<.001	<.001	3	5
STOMACH	HCFC1 →	-0.968	-1.542	.001	.003	3	5
BLOOD_Leukemia	ZNF48 →	-1.028	-1.002	<.001	.005	3	4
BLOOD_Leukemia	SPINDOC →	-2.203	-1.455	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MVD by L-cystine transport activity — BREAST

Explore this box plot interactively →