Neutral amino acid transport

Across TCGA patient cohorts, RNA activity of the Neutral amino acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAP, SIPA1, and DAB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutral amino acid transport activity versus FAP in COAD (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FAP →	+0.560	+0.026	.002	<.001	3	7
GBM	SIPA1 →	+0.374	+0.067	<.001	<.001	3	7
GBM	DAB2 →	+0.506	+0.051	<.001	<.001	3	6
LSCC	ABCF1_S166 →	+0.605	+0.031	.001	.008	3	6
GBM	COL3A1 →	+1.011	+0.051	<.001	<.001	3	6
GBM	GFPT2 →	+0.510	+0.040	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015804 vs FAP — COAD

Explore this scatter interactively →