Neutral amino acid transport

Across TCGA pan-cancer cohorts, RNA activity of the Neutral amino acid transport pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 58 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Neutral amino acid transport pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCS, show the opposite pattern, with higher activity associated with better survival.

UVM, BLCA, and KICH are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.440	0.964	<.001	98	view →
BLCA	OS	Median	All	0.526	0.654	.003	68	view →
KICH	OS	Quartile	All	0.282	0.936	<.001	62	view →
HNSC	OS	Median	IV	0.747	0.551	.001	58	view →
LIHC	OS	Median	All	0.372	0.619	<.001	57	view →
ACC	OS	Quartile	II,III,IV	0.256	0.920	.001	40	view →
UCS	OS	Tertile	II,III,IV	0.612	0.245	.017	24	view →
DLBC	OS	Tertile	IV	0.172	0.822	.014	21	view →
ESCA	OS	Tertile	All	0.406	1.000	.008	21	view →
STAD	OS	Tertile	All	0.240	0.510	.005	19	view →
THYM	OS	Median	All	0.643	1.000	.002	19	view →
UCEC	DFS	Median	All	0.782	0.874	.002	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0015804–UVM (OS)

Open the UVM breakdown →