Neutral amino acid transport

Across TCGA patient cohorts, RNA activity of the Neutral amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGIS, N4BP2L1, and RAB3D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutral amino acid transport activity versus PTGIS in HNSC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PTGIS →	-1.260	-0.301	<.001	.001	3	5
LSCC	N4BP2L1 →	-0.430	-0.518	.006	.007	2	6
HNSC	RAB3D →	+0.637	+0.308	<.001	.004	3	4
HNSC	MGP →	-0.959	-0.261	.004	.004	3	4
HNSC	CYP1B1 →	-1.249	-0.253	<.001	.001	3	4
HNSC	PARVG →	-0.630	-0.297	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015804 vs PTGIS — HNSC

Explore this scatter interactively →