Neutral amino acid transport

Across TCGA cell cohorts, RNA activity of the Neutral amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC7A5, GPC1, and SLC2A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutral amino acid transport activity versus SLC7A5 in LUNG_NSCLC_LUAD (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SLC7A5 →	+1.810	+0.208	<.001	<.001	3	7
LIVER	GPC1 →	+2.832	+0.281	.002	.009	3	7
LARGE_INTESTINE	SLC2A1 →	+2.510	+0.252	<.001	<.001	3	5
CNS	SNU13 →	-0.527	-0.245	.007	.009	2	6
LIVER	ATP6V0E1 →	+1.086	+0.380	<.001	.002	3	5
OVARY	NTHL1 →	-0.835	-0.226	.009	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015804 vs SLC7A5 — LUNG_NSCLC_LUAD

Explore this scatter interactively →