Branched-chain amino acid transport

Across TCGA patient cohorts, RNA activity of the Branched-chain amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCLK1, SLC25A14P1, and PRICKLE2-AS3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branched-chain amino acid transport activity versus DCLK1 in BRCA (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DCLK1 →	-0.870	-0.461	.006	.002	3	3
BRCA	SLC25A14P1 →	-0.202	-0.419	<.001	.002	3	3
BRCA	PRICKLE2-AS3 →	-0.109	-0.417	<.001	.002	3	3
PDAC	C12orf42 →	-0.468	-0.647	<.001	<.001	3	3
UCEC	MTND4P15 →	-0.664	-0.643	.001	.006	3	3
PDAC	LINC02768 →	-0.528	-0.505	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015803 vs DCLK1 — BRCA

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