Aromatic amino acid transport

Across TCGA patient cohorts, RNA activity of the Aromatic amino acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPRD2_S928, SIN3A, and RNASE3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aromatic amino acid transport activity versus RPRD2_S928 in LSCC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPRD2_S928 →	-0.432	-0.082	<.001	<.001	3	6
LSCC	SIN3A →	-0.255	-0.082	<.001	<.001	3	5
PDAC	RNASE3 →	+0.735	+0.045	.006	.003	3	5
LUAD	SERPINE1 →	+0.970	+0.065	<.001	<.001	3	5
LSCC	CCAR1 →	-0.208	-0.057	<.001	<.001	3	5
LSCC	HDAC1 →	-0.213	-0.065	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015801 vs RPRD2_S928 — LSCC

Explore this scatter interactively →