Acidic amino acid transport

Across TCGA patient cohorts, RNA activity of the Acidic amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUF2, SPAG5, and SH3RF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acidic amino acid transport activity versus NUF2 in BRCA (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NUF2 →	-0.844	-0.760	.001	<.001	3	7
GBM	SPAG5 →	-0.445	-0.246	.008	.003	3	6
LUAD	SH3RF1 →	+0.337	+0.344	.006	.005	3	5
GBM	DLGAP5 →	-0.989	-0.319	.001	.002	3	5
BRCA	KIF20B →	-0.706	-0.771	<.001	<.001	3	5
GBM	HASPIN →	-0.648	-0.379	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015800 vs NUF2 — BRCA

Explore this scatter interactively →