Glycerol transmembrane transport

Across TCGA patient cohorts, RNA activity of the Glycerol transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FCN1, VNN2, and ICAM3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerol transmembrane transport activity versus FCN1 in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCN1 →	+1.352	+0.117	<.001	<.001	3	7
PDAC	VNN2 →	+0.991	+0.121	<.001	<.001	3	7
PDAC	ICAM3 →	+0.816	+0.146	<.001	<.001	3	7
GBM	ITGAM →	+0.750	+0.111	<.001	.001	3	7
PDAC	ARG1 →	+0.982	+0.131	<.001	<.001	3	7
LSCC	GAR1 →	-0.450	-0.132	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015793 vs FCN1 — GBM

Explore this scatter interactively →