Galactose transmembrane transport

Across TCGA cell cohorts, RNA activity of the Galactose transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC48A1, ARHGEF6, and ANKRD42, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC48A1 grouped by Galactose transmembrane transport-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC48A1 →	-2.518	-1.838	<.001	<.001	3	4
SOFT_TISSUE	ARHGEF6 →	+2.456	+1.606	.001	<.001	3	4
SOFT_TISSUE	ANKRD42 →	-0.812	-1.167	.004	.004	3	4
SOFT_TISSUE	POU4F1 →	+3.095	+1.274	.002	.001	3	4
SOFT_TISSUE	TMSB15B →	+3.546	+1.603	.001	<.001	3	4
SOFT_TISSUE	FKBP7 →	+2.182	+1.550	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC48A1 by Galactose transmembrane transport activity — SOFT_TISSUE

Explore this box plot interactively →