C4-dicarboxylate transport

Across TCGA patient cohorts, RNA activity of the C4-dicarboxylate transport pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYSLTR2, CCDC102B, and VSNL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C4-dicarboxylate transport activity versus CYSLTR2 in COAD (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CYSLTR2 →	-0.358	-0.164	.001	<.001	3	5
PDAC	CCDC102B →	-0.486	-0.538	.002	.001	3	5
GBM	VSNL1 →	+1.673	+0.294	.001	<.001	3	4
HNSC	PODN →	-0.721	-0.245	.008	.001	3	4
LSCC	ENOX1 →	-0.350	-0.144	.001	.007	3	4
PDAC	FCRLA →	-0.554	-0.360	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015740 vs CYSLTR2 — COAD

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