C4-dicarboxylate transport

Across TCGA pan-cancer cohorts, RNA activity of the C4-dicarboxylate transport pathway is associated with patient survival in 30 of 34 cancer lineages. Pathway activity is summarized from the expression of its 27 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher C4-dicarboxylate transport pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and KIRC, show the opposite pattern, with higher activity associated with better survival.

UVM, BLCA, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.314	0.922	<.001	96	view →
BLCA	DFS	Median	IV	0.371	0.562	.001	75	view →
KIRP	DFS	Tertile	All	1.000	0.511	<.001	58	view →
ACC	OS	Tertile	All	0.369	0.745	.001	56	view →
KIRC	OS	Quartile	II,III,IV	0.909	0.700	<.001	52	view →
BRCA	DFS	Median	All	0.926	0.881	.006	42	view →
UCEC	OS	Tertile	All	0.883	0.953	.002	36	view →
LGG	DFS	Quartile	All	0.591	0.793	<.001	32	view →
STAD	OS	Tertile	IV	0.511	0.136	.009	29	view →
HNSC	DFS	Median	II,III,IV	0.493	0.276	.003	28	view →
READ	OS	Tertile	III,IV	0.858	0.574	.012	25	view →
SCLC	OS	Median	All	0.788	0.619	.011	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

GO:0015740–UVM (OS)

Open the UVM breakdown →