C4-dicarboxylate transport

Across TCGA cell cohorts, RNA activity of the C4-dicarboxylate transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM81A, RITA1, and SLC39A6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, C4-dicarboxylate transport activity versus FAM81A in LUNG_SCLC (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FAM81A →	-1.133	-0.655	.001	.005	3	4
BLOOD_Lymphoma	RITA1 →	-1.025	-0.782	.002	.001	3	3
BLOOD_Lymphoma	SLC39A6 →	+0.955	+0.522	.004	.008	3	3
BLOOD_Lymphoma	PDXP →	-0.836	-0.533	.002	.003	3	3
BLOOD_Lymphoma	SNRPA →	-0.464	-0.593	.001	.001	3	3
STOMACH	SLC33A1 →	+0.614	+0.287	<.001	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015740 vs FAM81A — LUNG_SCLC

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