Prostaglandin transport

Across TCGA patient cohorts, RNA activity of the Prostaglandin transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A12, PRTN3, and KDM5A_S1331, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostaglandin transport activity versus S100A12 in UCEC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S100A12 →	+1.236	+0.057	<.001	<.001	3	8
GBM	PRTN3 →	+0.922	+0.063	.001	<.001	3	8
OV	KDM5A_S1331 →	-0.881	-0.051	<.001	<.001	3	7
GBM	PNN →	-0.259	-0.058	.006	<.001	3	7
GBM	S100A8 →	+1.138	+0.056	<.001	<.001	3	7
UCEC	S100A9 →	+0.964	+0.047	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015732 vs S100A12 — UCEC

Explore this scatter interactively →