Prostaglandin transport

Across TCGA cell cohorts, RNA activity of the Prostaglandin transport pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO15B, NAA20, and B3GALT5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYO15B grouped by Prostaglandin transport-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MYO15B →	+1.534	+1.077	.006	.007	2	6
URINARY_TRACT	NAA20 →	-1.126	-1.968	<.001	<.001	3	4
CNS	B3GALT5 →	-0.515	-0.702	.001	.004	3	4
LUNG_NSCLC_LUAD	IL4I1 →	-0.564	-0.789	.002	<.001	3	4
OVARY	NSMF →	+1.087	+0.991	.002	.003	3	4
BONE	LRRC37A3 →	+1.715	+0.711	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYO15B by Prostaglandin transport activity — SOFT_TISSUE

Explore this box plot interactively →