Prostaglandin transport

Across TCGA cell cohorts, RNA activity of the Prostaglandin transport pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYDGF, FABP12, and IL25, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYDGF grouped by Prostaglandin transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MYDGF →	+0.246	+0.277	<.001	<.001	3	4
OESOPHAGUS	FABP12 →	+0.112	+0.240	.002	.008	3	4
BREAST	IL25 →	+0.217	+0.994	.008	.004	3	4
KIDNEY	SMYD5 →	+0.150	+0.291	.001	.003	3	3
KIDNEY	EDAR →	+0.164	+0.273	.004	<.001	3	3
KIDNEY	MCTP1 →	+0.195	+0.262	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYDGF by Prostaglandin transport activity — OVARY

Explore this box plot interactively →