Monocarboxylic acid transport

Across TCGA cell cohorts, RNA activity of the Monocarboxylic acid transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLXNB2, F3, and TDRKH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLXNB2 grouped by Monocarboxylic acid transport-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PLXNB2 →	-1.216	-1.516	.005	<.001	3	5
PANCREAS	F3 →	-3.433	-0.917	<.001	<.001	3	5
BLOOD_Leukemia	TDRKH →	+1.290	+1.103	.009	<.001	3	5
BLOOD_Myeloma	PIMREG →	+2.966	+1.465	<.001	<.001	3	5
URINARY_TRACT	DARS2 →	+1.176	+2.052	.007	<.001	3	5
PANCREAS	SUSD6 →	-1.210	-1.464	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLXNB2 by Monocarboxylic acid transport activity — STOMACH

Explore this box plot interactively →