Monocarboxylic acid transport

Across TCGA cell cohorts, RNA activity of the Monocarboxylic acid transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ETV5, RSRC2, and IL32, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monocarboxylic acid transport activity versus ETV5 in BREAST (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ETV5 →	-1.647	-0.211	.007	.004	3	6
SOFT_TISSUE	RSRC2 →	+0.807	+0.487	.004	.005	3	5
BLOOD_Lymphoma	IL32 →	-3.563	-0.230	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	TRMT10B →	+0.992	+0.308	.004	.003	3	4
LARGE_INTESTINE	PLAT →	-1.924	-0.218	.008	.001	3	4
LARGE_INTESTINE	TCTN3 →	-0.699	-0.230	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015718 vs ETV5 — BREAST

Explore this scatter interactively →