Bicarbonate transport

Across TCGA patient cohorts, RNA activity of the Bicarbonate transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC4A4, LDHAL6EP, and NME5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bicarbonate transport activity versus SLC4A4 in PDAC (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC4A4 →	+1.399	+1.581	<.001	<.001	3	8
PDAC	LDHAL6EP →	+1.161	+1.648	<.001	<.001	3	5
BRCA	NME5 →	+0.929	+0.704	.006	.001	3	5
COAD	ARHGAP44 →	+0.624	+0.498	.001	.007	3	5
PDAC	HPN →	+1.223	+1.467	.001	<.001	3	4
PDAC	NR1H4 →	+0.746	+1.336	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015701 vs SLC4A4 — PDAC

Explore this scatter interactively →