Organic cation transport

Across TCGA patient cohorts, RNA activity of the Organic cation transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AUH, NOC2L_S49, and CHDH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organic cation transport activity versus AUH in BRCA (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AUH →	+0.433	+0.042	<.001	<.001	3	6
CCRCC	NOC2L_S49 →	-0.343	-0.038	<.001	<.001	3	6
BRCA	CHDH →	+0.505	+0.028	<.001	<.001	3	5
UCEC	ACADS →	+0.607	+0.062	<.001	<.001	3	5
BRCA	PLOD1 →	-0.575	-0.047	<.001	<.001	3	5
BRCA	ARHGEF2 →	-0.453	-0.045	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015695 vs AUH — BRCA

Explore this scatter interactively →