Organic cation transport

Across TCGA pan-cancer cohorts, RNA activity of the Organic cation transport pathway differs between tumor and matched normal tissue in 9 of the 18 cancer types tested.

The strongest signal is observed in kidney chromophobe (KICH), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and KIRP, show the opposite pattern, with lower activity in tumor tissue.

KICH, KIRP, and LIHC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KICH	All	II,III,IV	−0.038	<.001	10	view →
KIRP	All	All	−0.027	<.001	7	view →
LIHC	Male	All	−0.031	<.001	6	view →
BRCA	All	III,IV	−0.028	<.001	6	view →
KIRC	All	All	−0.016	.001	6	view →
LUAD	Female	II,III,IV	+0.026	<.001	5	view →
READ	Male	All	−0.056	.006	3	view →
THCA	Male	IV	+0.026	.016	2	view →
CHOL	All	All	−0.037	.019	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 9 strongest of 9 lineages.

GO:0015695–KICH

Open the KICH breakdown →