Organic cation transport

Across TCGA patient cohorts, RNA activity of the Organic cation transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH4A1, COL15A1, and RHOJ, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organic cation transport activity versus ALDH4A1 in GBM (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ALDH4A1 →	+0.588	+0.716	.009	.003	3	4
GBM	COL15A1 →	-0.755	-0.734	<.001	<.001	3	4
HNSC	RHOJ →	-0.744	-0.294	<.001	.002	3	4
HNSC	PEAR1 →	-0.569	-0.198	<.001	.005	3	4
LUAD	ABHD4 →	+0.619	+0.417	<.001	.002	3	3
COAD	RPL36AP48 →	+0.122	+0.745	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015695 vs ALDH4A1 — GBM

Explore this scatter interactively →