Organic cation transport

Across TCGA cell cohorts, RNA activity of the Organic cation transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDPGP1, EFNA4, and SFXN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organic cation transport activity versus GDPGP1 in BREAST (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GDPGP1 →	-0.572	-0.188	.002	.004	3	5
LUNG_NSCLC_LUAD	EFNA4 →	-0.851	-0.225	<.001	.003	3	5
KIDNEY	SFXN2 →	-1.422	-0.318	<.001	.002	3	4
KIDNEY	TNXB →	+1.055	+0.343	.007	<.001	3	4
URINARY_TRACT	DGAT2 →	-2.190	-0.393	.003	<.001	3	4
LARGE_INTESTINE	CEP128 →	+0.486	+0.212	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015695 vs GDPGP1 — BREAST

Explore this scatter interactively →