DNA integration

Across TCGA patient cohorts, RNA activity of the DNA integration pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACTR2, TRIM21_S266, and FERMT3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA integration activity versus ACTR2 in LSCC (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ACTR2 →	-0.203	-0.062	<.001	<.001	3	9
PDAC	TRIM21_S266 →	-0.797	-0.043	.001	<.001	3	8
GBM	FERMT3 →	-0.474	-0.051	.001	.001	3	8
LUAD	UNC13D →	-0.362	-0.050	<.001	<.001	3	8
GBM	ZMYND11 →	+0.293	+0.060	.003	<.001	3	8
GBM	FOSL2_S120 →	-0.586	-0.066	.003	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015074 vs ACTR2 — LSCC

Explore this scatter interactively →