DNA integration

Across TCGA pan-cancer cohorts, RNA activity of the DNA integration pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher DNA integration pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and KIRP, show the opposite pattern, with higher activity associated with better survival.

READ, KIRP, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	III,IV	0.719	0.278	<.001	69	view →
KIRP	DFS	Median	IV	0.685	0.040	.002	67	view →
MESO	OS	Median	All	0.526	0.261	<.001	62	view →
UCS	DFS	Tertile	IV	0.500	0.956	.038	24	view →
STAD	OS	Tertile	III,IV	0.361	0.647	.006	24	view →
KIRC	DFS	Tertile	III,IV	0.806	0.685	.010	22	view →
UVM	DFS	Median	III,IV	0.613	0.288	.011	19	view →
SKCM	OS	Median	All	0.248	0.484	.005	18	view →
COAD	DFS	Quartile	II,III,IV	0.619	0.352	.004	15	view →
BRCA	DFS	Tertile	All	0.493	0.618	.006	11	view →
SCLC	OS	Quartile	IV	0.164	0.608	.008	9	view →
CESC	OS	Median	All	0.923	0.838	.010	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0015074–READ (OS)

Open the READ breakdown →