DNA integration

Across TCGA patient cohorts, RNA activity of the DNA integration pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF233, COMMD2, and RPS29P23, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA integration activity versus ZNF233 in HNSC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF233 →	+0.691	+0.116	.001	.005	3	4
UCEC	COMMD2 →	+0.298	+0.144	.007	.001	3	4
CCRCC	RPS29P23 →	+0.542	+0.123	.004	.004	3	4
BRCA	BTD →	+0.551	+0.158	.002	<.001	3	4
BRCA	SETMAR →	+0.604	+0.210	<.001	<.001	3	4
PDAC	AMY2B →	+1.310	+0.086	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015074 vs ZNF233 — HNSC

Explore this scatter interactively →