DNA integration

Across TCGA cell cohorts, RNA activity of the DNA integration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFI6, PSMD11, and WDR61, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFI6 grouped by DNA integration-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IFI6 →	-1.976	-1.125	<.001	.005	3	4
STOMACH	PSMD11 →	-1.060	-1.572	<.001	<.001	3	3
STOMACH	WDR61 →	-0.444	-1.221	.001	.001	3	3
OESOPHAGUS	TTLL12 →	+1.128	+0.382	<.001	.003	3	3
BREAST	CRTC3 →	-1.171	-1.563	.001	<.001	3	3
OESOPHAGUS	STK36 →	-1.182	-0.383	<.001	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFI6 by DNA integration activity — LUNG_SCLC

Explore this box plot interactively →