Heparan sulfate proteoglycan biosynthetic process

Across TCGA patient cohorts, RNA activity of the Heparan sulfate proteoglycan biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL3A1, COL1A1, and CTHRC1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heparan sulfate proteoglycan biosynthetic process activity versus COL3A1 in CCRCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	COL3A1 →	+0.602	+0.024	<.001	.001	3	7
GBM	COL1A1 →	+1.008	+0.039	<.001	.008	3	6
COAD	CTHRC1 →	+0.947	+0.042	<.001	<.001	3	6
COAD	SERPINH1 →	+0.445	+0.032	<.001	<.001	3	5
CCRCC	TGFBI_S649 →	+0.756	+0.020	.001	.007	3	5
COAD	TIMP2 →	+0.467	+0.025	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015012 vs COL3A1 — CCRCC

Explore this scatter interactively →