Heparan sulfate proteoglycan biosynthetic process

Across TCGA patient cohorts, RNA activity of the Heparan sulfate proteoglycan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDIA3, LOX, and CPE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heparan sulfate proteoglycan biosynthetic process activity versus PDIA3 in BRCA (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PDIA3 →	+0.402	+0.201	.006	<.001	3	4
GBM	LOX →	+1.126	+0.333	.003	<.001	3	4
LUAD	CPE →	+1.071	+0.111	.005	<.001	3	3
OV	FABP3 →	-0.989	-0.159	.002	.006	3	3
LUAD	PSMB8-AS1 →	-0.294	-0.072	.002	.005	3	3
LUAD	RPL39P5 →	-0.326	-0.095	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0015012 vs PDIA3 — BRCA

Explore this scatter interactively →