Heparan sulfate proteoglycan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Heparan sulfate proteoglycan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSF2BP, HSD17B10, and LAMP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSF2BP grouped by Heparan sulfate proteoglycan biosynthetic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HSF2BP →	-0.437	-0.945	.003	<.001	3	4
CNS	HSD17B10 →	+0.490	+0.801	.003	.006	3	4
LARGE_INTESTINE	LAMP3 →	+1.334	+0.725	.001	.001	3	4
LIVER	MCEE →	+0.809	+1.400	.004	<.001	3	3
LIVER	DUSP11 →	+0.568	+1.297	.002	.006	3	3
BLOOD_Lymphoma	STX2 →	-1.206	-1.307	.002	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSF2BP by Heparan sulfate proteoglycan biosynthetic process activity — SKIN

Explore this box plot interactively →