Negative regulation of smooth muscle cell migration

Across TCGA patient cohorts, RNA activity of the Negative regulation of smooth muscle cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP7, CNRIP1, and DACT1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of smooth muscle cell migration activity versus IGFBP7 in LSCC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IGFBP7 →	+0.900	+0.208	<.001	<.001	3	8
BRCA	CNRIP1 →	+0.808	+0.378	<.001	.008	3	7
HNSC	DACT1 →	+0.919	+0.276	.002	.006	3	7
OV	PABPC5 →	+0.485	+0.148	<.001	.002	3	7
LSCC	CACNA1C →	+0.657	+0.231	<.001	<.001	3	7
LUAD	PDLIM3 →	+0.704	+0.279	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014912 vs IGFBP7 — LSCC

Explore this scatter interactively →