Negative regulation of smooth muscle cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of smooth muscle cell migration pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKP2, SARNP, and LAD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PKP2 grouped by Negative regulation of smooth muscle cell migration-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PKP2 →	-2.054	-0.908	.001	.003	3	5
UPPER_AERODIGESTIVE_TRACT	SARNP →	-0.988	-0.302	.002	<.001	3	4
URINARY_TRACT	LAD1 →	-5.515	-1.470	<.001	.005	3	4
URINARY_TRACT	SNTB2 →	+1.080	+1.990	<.001	<.001	3	4
URINARY_TRACT	ERBB3 →	-4.312	-1.584	<.001	.005	3	4
BLOOD_Leukemia	KRBOX4 →	+0.712	+1.456	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PKP2 by Negative regulation of smooth muscle cell migration activity — OVARY

Explore this box plot interactively →