Negative regulation of smooth muscle cell migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of smooth muscle cell migration pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LASP1, LDLRAD2, and ENTR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of smooth muscle cell migration activity versus LASP1 in LARGE_INTESTINE (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LASP1 →	+0.733	+0.261	.002	<.001	3	5
BREAST	LDLRAD2 →	+0.815	+0.305	.001	.002	3	5
LIVER	ENTR1 →	-1.038	-0.427	.004	.002	3	5
PANCREAS	ADAM9 →	+1.425	+0.283	.009	.004	3	5
PANCREAS	WDR1 →	+0.725	+0.246	<.001	<.001	3	5
BONE	SMARCC1 →	-1.436	-0.327	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014912 vs LASP1 — LARGE_INTESTINE

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