Satellite cell activation involved in skeletal muscle regeneration

pathway activity — cross-omics
GO:0014901Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Satellite cell activation involved in skeletal muscle regeneration pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KPNA1, ROGDI, and CCDC58, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCKPNA1 →+0.273+0.097<.001<.00136
LSCCROGDI →-0.172-0.083<.001<.00135
LUADCCDC58 →+0.374+0.078<.001<.00135
BRCAMDM1_T515 →-0.492-0.074<.001<.00135
LSCCARHGAP18 →-0.245-0.089<.001<.00135
BRCATLE5 →-0.322-0.074<.001.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration