Satellite cell activation involved in skeletal muscle regeneration

pathway activity — cross-omics
GO:0014901Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Satellite cell activation involved in skeletal muscle regeneration pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPT2, PTPRB, and MYCN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACGPT2 →-0.518-0.438.001.00333
UCECPTPRB →-0.426-0.405.001.00633
UCECMYCN →-0.908-0.450.008.00233
LSCCFAM83C →+1.520+0.630.005<.00133
LSCCEIF5A →+0.570+0.634<.001<.00133
LSCCPPP1R36 →-0.300-0.461.002.00733
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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