Muscle hypertrophy

Across TCGA patient cohorts, RNA activity of the Muscle hypertrophy pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S102, TTC7B, and CNRIP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Muscle hypertrophy activity versus TNS2_S102 in OV (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TNS2_S102 →	+0.737	+0.030	.001	.003	3	8
UCEC	TTC7B →	+0.380	+0.051	<.001	<.001	3	8
BRCA	CNRIP1 →	+0.784	+0.039	<.001	<.001	3	8
CCRCC	PALM2AKAP2 →	+0.491	+0.038	<.001	<.001	3	8
HNSC	SYNPO →	+0.560	+0.043	<.001	<.001	3	8
CCRCC	UTRN →	+0.257	+0.032	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014896 vs TNS2_S102 — OV

Explore this scatter interactively →